Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities
Soft matter science and the COVID-19 pandemic
Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
As a national exam with more than 1 million test takers every year, the National Postgraduates Entrance Examination is very important for students' academic life, and cheating incidents have been exposed from time to time.
Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
Life's ups and downs
Trends and targets in antiviral phototherapy
Detroit Three: The other two Michigan-based manufacturers still face bumps. General Motors copes with continued fallout from its ignition switch recall while Ford fights through the most aggressive launch period in the company’s history.
Singer Susan Boyle came undone -- literally, when her trousers popped open at a soccer match as she waved a Celtic fan above her head in Scotland. The "Britain
A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
People who are skeptical about this argument just need look at smartphones and personal computers, which have served as the technological driving force of the past century.
Novel biosensing methodologies for ultrasensitive detection of viruses
Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
As a result, 39 percent of the post-90s generation tries to avoid the negative effects of mobile phone use through measures like turning off app notifications, intentionally limiting the frequency of social media interactions and staying away from social media entirely in certain situations.
ACE2 as a potential therapeutic target for pandemic COVID-19
Her real-life sister Lexie often accompanies her dressed as Elsa's sister Princess Anna from the movie, and her best friend steps in when Lexie isn't available.
The pickup in consumption in turn will entice businesses to hire and invest more to keep up with rising sales. The result: The U.S. is likely to grow more than 3% for the first time since 2005.
Diagnostic technologies for COVID-19: a review
Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
Dachis says: Adidas added more than 34 million new fans and followers in just 12 months this year. The company put that audience to good use and benefited from high levels of positive discussion all year long.
An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Canadian schools continue to lose ground. Only three remain in the ranking compared with five last year and all fall about six places. Among these, Rotman School of Management at the University of Toronto is the highest ranked at 65, while Smith School of Business at Queen’s University is bottom of the table in 100th place.
Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
周边环境：斯托宁顿位于康涅狄格州东南部的小纳拉甘西特湾(Little Narragansett Bay)，从哈特福特(Hartford)和罗德岛的普罗维登斯(Providence, R.I.)开车约1小时可达，从纽约市开车约3小时。这里曾是一个具有悠久历史的繁忙港口，至今仍然保留着一支商业捕鱼船队，有几个分布着殖民式和联邦式建筑的历史区，以及一个繁荣的航海社区。在该镇的一端有个小型的公共海滩，而在另一端罗德岛的沃奇·希尔(Watch Hill)则有个大得多的海滩，开车大约20分钟可到。这栋希腊复兴式房屋带有此类建筑必不可少的爱奥尼亚柱和山形墙上的扇骨半圆窗，房屋就坐落在市镇中心。
Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
Sixty-one percent of Chinese college students who graduated in 2014 are satisfied with their current jobs, a survey has revealed.
In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
The three-day China Development Forum 2016 kicked off in Beijing.
Antiviral drug discovery: broad-spectrum drugs from nature
She was also recognised for being the youngest recipient of the Ripple of Hope Award from the Robert F. Kennedy Center for her charity work.
3. Kraft. Brand love: -10% / Rank: 11
Or, this year, to be women with a story to tell about abuse, sexual or otherwise — a couple of whom shared #MeToo moments in our pages. Carlotta Gall told the story of Henda Ayari, a French citizen of North African heritage and anti-Salafist activist who accused a prominent Oxford professor of raping her.
2.German: 22.2 percent increase
Influenza neuraminidase: A druggable target for natural products
X-Men: Apocalypse is said to hit theatres on May 27, 2016.
"If it (transforming the economic development mode) only results in empty talk instead of being implemented, then economic development cannot be promoted in a sound and rapid way, and may even not be sustained." LI YIZHONG, member of the CPPCC National Committee and former minister of industry and information technology
I mean, is it worth to be a No. 8 seed with Serge Ibaka and Jeff Green leading the way? Maybe it is. This all just seems awfully backwards.
Domestically, an increasingly active middle class is generating pressure for more accountable governance. Mounting inequalities have nurtured a sense of injustice; 200m migrant workers remain second-class citizens and corruption is worsening. Tackling these problems is urgent, but China's economic successes have fostered an unwarranted self-confidence. Instead, motivated by the Arab spring, the system has moved aggressively to contain any social discontent that might spark more politically sensitive movements.
Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
Do you feel any of your worksare underrated or wished was a little bit more popular?
Here's how the pay of prime ministers and presidents of the world's biggest economies stacks up, according to official data and converted into US dollars at market rates.
The role of biosensors in the detection of emerging infectious diseases
James Bond Themes 6. "A View to a Kill" by Duran Duran
Quantitative determination of mechanical stability in the novel coronavirus spike protein
Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
5. Women keep rising.
What Mr Ravenscroft liked about it when he was choosing his graduate career path was that it of-fered the best of two worlds. He would be fast-tracked into the classroom, earning a salary, being mentored by an executive from the private sector and making contacts with business; in return, he would commit to teaching for two years and complete a teacher training qualification.
MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
Two-thirds of this year’s deals are trading above their issue price. On average, 2017’s class of US IPOs have risen in value by about double the S&P 500, at 20 per cent, according to Renaissance Capital, which runs IPO-focused exchange traded funds.
Truck wars: Awards aside, Ford’s aluminum pickup is hard to build and slow to sell, leaving an opening for Ram’s fast-rising 1500 while Nissan tries to forget the failure of its first full-size truck when it launches the second-generation Titan with the biggest of big rig styling. The industry’s biggest secret is revealed by veteran executive John Krafcik in Automotive News: In the
Remedy: When we make a major decision such as accepting (or turning down) a job offer, we tend to exercise confirmation bias. If we think we made a good choice, we prioritize information that supports this view and if we fear we’ve made a mistake, we zero in on intel or impressions that reinforce this gut feeling. If you habitually doubt your competence when it comes to making career decisions, the issue is less about the subjective quality of your past choices and more about building confidence in your ability to guide your career in a satisfying direction and exert some degree of control over the outcomes of your choices. Addressing this could involve recalling the circumstances under which you made a particular choice and the priorities you held at the time and noting how they differ from the circumstances and priorities under which you’re evaluating those decisions. It could also involve working with a career coach to identify patterns in your decision-making and to help you bolster areas in which you’d like to increase your confidence – risk taking or negotiation, for example.
Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
Local-level work experience will advantageous for applicants, with personnel with more than two years of experience at this level given some advantage.
Inhibition of SARS coronavirus helicase by bismuth complexes
Managers are able to reward their subordinates in unique, personalized ways thanks to the budget they receive from corporate. Two examples of past bonuses: free trail rides at an equestrian stadium and a barbeque with lassoing and horseshow throwing lessons.
Emily Ratajkowski managed to steal the show, opting for a seriously saucy twist on the classic ballgown. Opting for a semi-sheer lacey black number, the We Are Your Friends actress ensured her world-famous figure was on display.
Apple Inc., Alphabet Inc.'s Google, and Coca-Cola Co. topped the list of the world's 100 most valuable brands in 2016, while technology and automotive brands dominated the overall rankings, according to a new report from brand consultancy Interbrand.
Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
Best Companies rank: 1
The former Miss World Priyanka Chopra stands 9th on the world's most beautiful women of 2015 list. She is an Indian film actress and singer. She is one of Bollywood's highest-paid actresses and one of the most popular and high-profile celebrities in India. She has received numerous accolades, including a National Film Award for Best Actress and Filmfare Awards in four categories.
The top 10 Weibo celebrities now have a combined 40 million followers. One of the most famous online figures, Papi Jiang, already signed a contract for video ads worth a staggering $3.4 million.
A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
The Republican candidate appeared unsure at times and occasionally stumbled over his lines as if struggling to remember his briefing notes. He began sweating as Obama, aggressive from the start, got the better of him during exchanges on Iran, Iraq and Russia as well as on US military spending.
位于第三位的是收入5.95千万的Fleetwood Mac，尽管这支乐队有三位男士，它也以拥有两位备受瞩目的女星为荣，她们是史蒂薇.妮克丝和最近回归的克莉丝汀麦克，是她们造就了本次上榜。乐队的巡回演唱会On With The Show在打分期间共有86场演唱会，在每个城市平均挣得超过1百万。
Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.
Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.
Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
“只要总体市场仍然相对积极，只要交易继续执行良好，我们继续预期今年余下时间会保持健康的交易量，”高盛(Goldman Sachs)美洲股票资本市场主管戴维?路德维格(David Ludwig)表示。
While oil prices may rebound in 2015, they almost certainly won't return to $100 a barrel any time soon, barring a geopolitical crisis in a major petroleum-producing region. So the gift will keep giving this year and further feed an accelerating U.S. recovery.
Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring
Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
（美联社）波多黎各，圣胡安市 － 波多黎各新总督周一宣誓就职，作为美国领土许多人认为要为新的紧缩措施做准备，并为该岛摆脱严重的经济危机重新推动建州或独立。
Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
Homing in on a brand that excels at making the kind of vehicle you’re looking for is an efficient way to focus your shopping and find the best car for you. The 2016 U.S. News Best Vehicle Brand awards recognize the best brands in four categories: Cars, SUVs, Trucks and Luxury.
Edgar Wright’s Baby Driver is one of the most entertaining thrill rides of this year, this decade. This century.
Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
People who are skeptical about this argument just need look at smartphones and personal computers, which have served as the technological driving force of the past century.
How do you feel about workingwith Ei Aoki again in Aldnoah?
Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
8. How to dip dye hair
Apple Inc. CEO Steve Jobs introduces the iPad 2 on stage during an Apple event in San Francisco, California in this March 2, 2011,
Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
Six regions recorded GDP growth less than 7 percent, with China's north-eastern rust belt Liaoning province at the bottom with negative growth.
The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
6. You don’t just pass in front of the TV if i’m watching football, you better crawl on the floor.
"We'll start with a broad list and then begin to narrow it," Podesta told the Boston Globe. "But there is no question that there will be women on that list."
Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
CareerCast.com, a career website owned by Adicio Inc., ranked 200 jobs from best to worst based on five criteria: physical demands, work environment, income, stress, and hiring outlook. The firm used data from the Bureau of Labor Statistics and other government agencies to determine the rankings. As in prior years, the 200 jobs were selected for their relevance in the current labor market as well as the availability of reliable data.
The Cnzz.com report also discusses the problem of the 'free-to-play' business model that's prevalent in China's online game sector. While many games companies in the U.S., for example, charge subscription fees, most Chinese games utilize the free-to-play model, which allows players to try out a game without paying. The longer players stay in the game, the more likely they will be to pay for in-game items to move up into higher levels of play. But that also means that people who spend the most money are the best performers.
Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
As for the fortunes of the gig economy, the UK will be a key country to watch. The government is due to respond to an independent review into whether British law is keeping up with this new trend. Bold policy action — either in favour or against online labour platforms — now seems less likely given the fragility of the government and the time-consuming nature of Brexit.
Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.
Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.
Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.
Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
The invulnerable singer broadened into a wider emotional palette – musical too, with guitars and brass lacing through synthetic beats and dub effects. It could recall art-rock godmother Kate Bush (see the single "Green Light").
A modular microarray imaging system for highly specific COVID-19 antibody testing
The best bosses understand the art of delegation. My commenter said something along the lines of, “They’ve fired themselves from their previous job,” meaning that they don’t interfere in the day-to-day and minute-to-minute workflow or processes. In essence, learning to delegate instead of micromanage is about trust。
Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
A string of other Victoria's Secret models have also been banned from the country including Julia Belyakova, Kate Grigorieva and Irina Sharipova - all from Russia - and Ukraine's Dasha Khylstun.
"People should just never walk away and leave their animals," Ms Lewis said. "Everyone has a legal obligation to look after animals in their care."
Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.
Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
On our increasingly human-dominated planet we can still learn much from the lives of other species. The discovery this year that the Greenland shark lives for 400 years, making it the longest-living vertebrate, puts our hectic lives into perspective.
A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
The Cems masters in management, the international programme provided through a network of 30 business schools, is ninth, down five places from 2015, when it was last ranked.
An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.
Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
都不是。1772年,一场空前的危机击中了阿姆斯特丹：一家受人尊敬的荷兰投资银团对不列颠东印度公司(British East India Company)股票的投资变成了一场灾难。
Against: Opening so early in the year outside of awards season could hinder its chances.
Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
A facile assay for rapid detection of COVID-19 antibodies
Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
Sliced into eight pieces, the pizza works out to $250 per slice, meaning it costs roughly $50 per bite.
Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Stand: Facebook CEO Mark Zuckerberg took a stand for immigration reform
Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
For those outside the scientific community, the response to the retraction has been mixed.
Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
It's important to remember that even when the overall number of jobs goes down, some companies are still adding workers -- it's just that others are cutting even more.
Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
One such development is 60 Water Street in Dumbo, a 290-unit rental with a 24-hour concierge and a roof deck offering Manhattan views. Leasing begins next month, with rent for a two-bedroom starting at a jaw-dropping $6,018 a month. “People want that condo-like living, even though they’re renting and not owning,” said Jodi Ann Stasse, the managing director of new developments for Citi Habitats.
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.
Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
Anti-HIV drug repurposing against SARS-CoV-2
Everyone on Wall Street, Main Street and Washington keeps forgetting the fundamentals of market cycles. Please remember: Investors Business Daily's Bill O'Neill, author of 'How to Make Money in Stocks, ' says market cycles average 3.75 years up, nine months down.
Guangdong has cemented its position as the country's largest provincial economy for the 28th consecutive year, with its gross domestic product (GDP) exceeding 7.9 trillion yuan in 2016.
位于华盛顿特区的乔治敦大学(Georgetown University)麦克多诺商学院(McDonough business school)重新回到了定制课程排行榜的第15位，去年，该校因客户调查反馈率低而未上榜。只有3所学校是首次登上定制课程排行榜，包括排名第60位的伦敦卡斯商学院(Cass Business School)。
Length-scale dependence of protein hydration-shell density
3 . 《歌剧魅影》（ T h e Phantom of the Opera ）是 由安德鲁·韦伯（Andrew Webber）作曲的著名音乐剧，剧中的男主人公“魅影”（Phantom）的右脸上戴着一副面具。
14. 《与外婆同行》(Grandma)，导演：保罗·韦兹(Paul Weitz)。
China's box office sales have increased from 1 billion yuan to 40 billion yuan in the past decade as the industry has adopted more market-oriented reform measures.
1997：H5N1传染人类1997: H5N1 Infects Humans
High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
The report found that students majoring in art, agriculture and engineering were more willing to start businesses, while those majoring in history and science showed relatively low interest.
A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
Beauty and Evolution
About this collection
The film critics of The New York Times — Manohla Dargis and A. O. Scott — share their picks for the best movies of the year.